Oxcarbazepine Therapy for Complete Central Diabetes Insipidus
نویسندگان
چکیده
Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. The patient maintained a normal serum sodium level and has had appropriately concentrated urine for 5 years on just oxcarbazepine, despite undetectable antidiuretic hormone (ADH) levels. This suggests that oxcarbazepine (or one of its metabolites) may stimulate collecting tubule V2 receptor-G protein complex independent of ADH, resulting in increased renal tubular water reabsorption. Oxcarbazepine may be useful as an alternative therapy for patients with central diabetes insipidus.
منابع مشابه
Physiology in Medicine: a Series of Articles Linking Medicine with Science
Diabetes insipidus is a condition in which patients produce large quantities of dilute urine. Central or neurogenic diabetes insipidus results from the failure of the posterior pituitary to make or secrete vasopressin (also called antidiuretic hormone [ADH]). Nephrogenic diabetes insipidus (NDI), which can be congenital or acquired, results from failure of the kidney to respond to vasopressin. ...
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